One molecule, two hormone signals
→ Semaglutide acts on one receptor: GLP-1.
→ Tirzepatide acts on two: GIP and GLP-1.
→ It's a single peptide of 39 amino acids.
→ Tomorrow: the head-to-head trial results. Turn on post notifications.
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Sources
Sources 📚
• US FDA prescribing information: Zepbound (tirzepatide), Wegovy (semaglutide)
• Coskun T, et al. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus. Molecular Metabolism, 2018;18:3–14.