2 minutes vs 1 week Same hormone family, very different lifespan.
→ Your own GLP-1 is cut apart by the enzyme DPP-4 within about 2 minutes.
→ Semaglutide has a half-life of about one week.
→ Two tricks: changes that resist DPP-4, and a fatty side chain that binds albumin in the blood.
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Sources
Sources 📚
• Holst JJ. The physiology of glucagon-like peptide 1. Physiological Reviews, 2007;87(4):1409–1439.
• Lau J, et al. Discovery of the Once-Weekly GLP-1 Analogue Semaglutide. Journal of Medicinal Chemistry, 2015;58(18):7370–7380.